Toxicity of depleted uranium complexes is independent of p53 activity

The Toxicity of Depleted Uranium

Depleted uranium (DU) is an emerging environmental pollutant that is introduced into the environment primarily by military activity. While depleted uranium is less radioactive than natural uranium, it still retains all the chemical toxicity associated with the original element. In large doses the kidney is the target organ for the acute chemical toxicity of this metal, producing potentially let...

Mitochondrial Toxicity of Depleted Uranium: Protection by Beta-Glucan

Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...

Mitochondrial Toxicity of Depleted Uranium: Protection by Beta-Glucan

Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...

What Is Depleted Uranium

T na m What Is Depleted Uranium? Depleted uranium is created as a byproduct during the processing of natural uranium to make it suitable for use as fuel in nuclear power plants or as a component in nuclear weapons. In natural uranium, 99.27% of the mass consists of atoms of uranium-238. About 0.72% of the mass consists of atoms of uranium-235, and a very small amount (0.0055% by mass) is uraniu...

toxicity of depleted uranium on isolated rat kidney mitochondria